The Bayern defender has been sent home due to a muscular problem, while the Leverkusen attacker is unavailable due to illness
Holger Badstuber and Karim Bellarabi have been ruled out of Germany's Euro 2016 qualifier against Georgia on Sunday due to injury and illness respectively.
The Bayern Munich defender made his first international appearance for two-and-a-half years in a 2-2 friendly draw with Australia on Wednesday, but was withdrawn at half-time.
Germany assistant coach Thomas Schneider has now revealed that the 26-year-old will not travel to Tbilisi for Sunday's Group D encounter at the Boris Paichadze Erovnuli Stadion due to muscular problems.
Schneider stressed that Badstuber's omission was precautionary, while Bellarabi - who also started against Australia - is ruled out as the Bayer Leverkusen attacker is suffering from a cold.
Joachim Low will take a 21-man squad to Georgia as the world champions attempt to keep the pressure on Group D leaders Poland.
Germany currently sit joint-second in their section with seven points from four games, trailing Poland by three points.
