The Chelsea striker is back in the European champions' set-up while the Sevilla star has been rewarded for his form this season
Vicente del Bosque has welcomed back Diego Costa to Spain's squad after the Chelsea striker missed both matches for the former world champions in November.
Costa was at the centre of a club-versus-country row last year as he struggled to maintain his fitness under the demands of playing at both levels.
A hamstring injury saw him miss the matches with Belarus and Germany in late 2014, but the Premier League's top scorer has returned to face Ukraine and Netherlands.
Del Bosque has also made room for potential debutants Sergio Asenjo and Vitolo, while Mikel San Jose and Mario Suarez are back in contention.
There is no place for Rayo Vallecano's Alberto Bueno, though, as the forward is unable to dislodge Pedro from the squad, despite netting 15 La Liga goals this season.
"Pedro is a good player and we believe in him," Del Bosque told reporters on Thursday. "He has always responded well for us.
"He is not a striker but he can open the field up for us. He's a very interesting player.
"We have brought in Vitolo because of everything he has done for Sevilla. We feel that he can be useful to us
"We also had the opportunity to reward Asenjo, who has been doing very well for Villarreal."
Meanwhile, Del Bosque reiterated that while David Villa retired from international football after last year's World Cup, he could yet call upon the New York City striker at some point in the future.
"Nobody has told me that Villa is not able to join up with the national team," the former Real Madrid boss added. "And there's still the possibility for him to return now. He is a player who remains very important for us."
Spain squad:
Goalkeepers: Sergio Asenjo (Villarreal), Iker Casillas (Real Madrid), David de Gea (Manchester United).
Defenders: Jordi Alba (Barcelona), Raul Albiol (Napoli), Marc Bartra (Barcelona), Juan Bernat (Bayern Munich), Dani Carvajal (Real Madrid), Juanfran (Atletico Madrid), Gerard Pique (Barcelona), Sergio Ramos (Real Madrid).
Midfielders: Sergio Busquets (Barcelona), Santi Cazorla (Arsenal), Cesc Fabregas (Chelsea), Andres Iniesta (Barcelona), Isco (Real Madrid), Koke (Atletico Madrid), Pedro (Barcelona), Mikel San Jose (Athletic Bilbao), David Silva (Manchester City), Mario Suarez (Atletico Madrid), Vitolo (Sevilla).
Forwards: Diego Costa (Chelsea), Alvaro Morata (Juventus).
